Located on Millstätter See, Carinthia, Austria. Designed by MHM Architects.
The things with which we concern ourselves in science appear in myriad forms, and with a multitude of attributes. For example, if we stand on the shore and look at the sea, we see the water, the waves breaking, the foam, the sloshing motion of the water, the sound, the air, the winds and the clouds, the sun and the blue sky, and light; there is sand and there are rocks of various hardness and permanence, color and texture. There are animals and seaweed, hunger and disease, and the observer on the beach; there may be even happiness and thought. Any other spot in nature has a similar variety of things and influences. It is always as complicated as that, no matter where it is. Curiosity demands that we ask questions, that we try to put things together and try to understand this multitude of aspects as perhaps resulting from the action of a relatively small number of elemental things and forces acting in an infinite variety of combinations.
For example: Is the sand other than the rocks? That is, is the sand perhaps nothing but a great number of very tiny stones? Is the moon a great rock? If we understood rocks, would we also understand the sand and the moon? Is the wind a sloshing of the air analogous to the sloshing motion of the water in the sea? What common features do different movements have? What is common to different kinds of sound? How many different colors are there? And so on. In this way we try gradually to analyze all things, to put together things which at first sight look different, with the hope that we may be able to reduce the number of different things and thereby understand them better.
Read all of them at Caltech
The MAPK/ERK pathway (also known as the Ras-Raf-MEK-ERK pathway) is a chain of proteins in the cell that communicates a signal from a receptor on the surface of the cell to the DNA in the nucleus of the cell.
The signal starts when a signaling molecule binds to the receptor on the cell surface and ends when the DNA in the nucleus expresses a protein and produces some change in the cell, such as cell division. The pathway includes many proteins, including MAPK (mitogen-activated protein kinases, originally called ERK, extracellular signal-regulated kinases), which communicate by adding phosphate groups to a neighboring protein, which acts as an “on” or “off” switch.
When one of the proteins in the pathway is mutated, it can be stuck in the “on” or “off” position, which is a necessary step in the development of many cancers. Components of the MAPK/ERK pathway were discovered when they were found in cancer cells. Drugs that reverse the “on” or “off” switch are being investigated as cancer treatments.
Through a series of unfortunate events I’ve been without a fridge and a freezer for almost 1 month now. My initial anger has since then almost vanished and eventually it turned out be a quite interesting – and still ongoing – social experiment. So what happened:
- I became more social
- I met more of my friends
- I spent more quality time with my girlfriend
- I started to think more about food and how much I should and from where it comes from
- I found out about a bunch of awesome new bars and restaurants I haven’t known before
- I’ve spent more money on food than usually (which is a postive effect imo)
- My kitchen has never been that clean in ages
- Really, there is no more dish washing
- I didn’t have to constantly run errands, which saved a lot of time
- I discovered a variety of new, smallish and exotic dishes, I wouldn’t have tried if going to a restaurant was something special (if I go to fancy restaurants, I like to order stuff I know so I reduce the likely hood of not being happy with my food)
- I became more active and sporty since I had to actively “seek” food somewhere
- When I bought food, I only did so in very small amounts and only the freshest of the freshest
- My electricity usage is less (and so is the bill)
- I stopped eating unhealthy, small stuff in between meals
- No more binge eating after getting home drunk
Thus, I recommend giving it a try.