An Old & Excellent Jean Paul Gaultier Commercial

The video quality is lousy considering the mesmerizing and simple beauty of that spot. Perfect bodies in a perfect setting. Strings attached.

The Best Letter To The Editor Ever Written

Probably the best and most entertaining Letter to the Editor ever written. An avid reader of The Economist informs the newspaper of the disappearance of his Hemorrhoids since “foolishly failing to renew” his subscription.

The Economist Letter to the Editor

You may want to follow The Economist’s Instagram feed here.

Via 33charts

Thought Maybe

A friend introduced me to a nifty site offering niche documentary film material – Thought Maybe. Some of it looks rather conspiration-affine, but overall some decent and off-mainstream films. They even have the full “All Wateched Over By The Machines of Loving Grace” Series, which is a must-watch.

Thought Maybe is an online repository of films covering topics challenging modern society, industrial civilisation, globalisation and dominant culture. This site is an independent and autonomous online library to inform, inspire and provoke action.

(Thanks to VB)

Warum Evidenz wichtig ist

Ein Artikel über Wissenschaft, Evidenz und Forschung nach einer “Diskussionrunde” auf Puls4. Voller Artikel ist hier zu lesen.

Warum Evidenz wichtig ist
Der Grund warum Flugzeuge fliegen, Diabetiker ein normales Leben führen können und wir wissen warum Menschen einen opponierenden Finger Ihr Eigen nennen beruht auf wissenschaftlicher Erkenntnis. Auf Evidenz, keinen Meinungen.

The Inception Horn

Ever since watching Inception I thought the horn sound used in the movie is really good sound design. Looks like I am not the only one.

Here you can listen to the Inception Horn.

The Perfect Lake House

Located on Millstätter See, Carinthia, Austria. Designed by MHM Architects.

The perfect boat house

The Feynman Lectures

The things with which we concern ourselves in science appear in myriad forms, and with a multitude of attributes. For example, if we stand on the shore and look at the sea, we see the water, the waves breaking, the foam, the sloshing motion of the water, the sound, the air, the winds and the clouds, the sun and the blue sky, and light; there is sand and there are rocks of various hardness and permanence, color and texture. There are animals and seaweed, hunger and disease, and the observer on the beach; there may be even happiness and thought. Any other spot in nature has a similar variety of things and influences. It is always as complicated as that, no matter where it is. Curiosity demands that we ask questions, that we try to put things together and try to understand this multitude of aspects as perhaps resulting from the action of a relatively small number of elemental things and forces acting in an infinite variety of combinations.

For example: Is the sand other than the rocks? That is, is the sand perhaps nothing but a great number of very tiny stones? Is the moon a great rock? If we understood rocks, would we also understand the sand and the moon? Is the wind a sloshing of the air analogous to the sloshing motion of the water in the sea? What common features do different movements have? What is common to different kinds of sound? How many different colors are there? And so on. In this way we try gradually to analyze all things, to put together things which at first sight look different, with the hope that we may be able to reduce the number of different things and thereby understand them better.

Read all of them at Caltech

Schematic MAP Kinase Pathways

The MAPK/ERK pathway (also known as the Ras-Raf-MEK-ERK pathway) is a chain of proteins in the cell that communicates a signal from a receptor on the surface of the cell to the DNA in the nucleus of the cell.

The signal starts when a signaling molecule binds to the receptor on the cell surface and ends when the DNA in the nucleus expresses a protein and produces some change in the cell, such as cell division. The pathway includes many proteins, including MAPK (mitogen-activated protein kinases, originally called ERK, extracellular signal-regulated kinases), which communicate by adding phosphate groups to a neighboring protein, which acts as an “on” or “off” switch.

When one of the proteins in the pathway is mutated, it can be stuck in the “on” or “off” position, which is a necessary step in the development of many cancers. Components of the MAPK/ERK pathway were discovered when they were found in cancer cells. Drugs that reverse the “on” or “off” switch are being investigated as cancer treatments.[1]